Are Melanosome Complexes Lysosomes?
نویسندگان
چکیده
منابع مشابه
Phagocytosis of melanosome-containing apoptotic cells by the neighbouring tumour cells appears to be followed by formation of melanosome complexes
Pigmented basal cell carcinomas can be difficult to distinguish clinically from melanoma. Dermoscopy has proven to be useful in the differential diagnosis of the two tumour types. SIAscopy (Spectrophotometric intracutaneous analysis) is a fairly new technique of imaging pigmented skin lesions that has been presented previously as a useful tool in diagnosing melanoma. The aim of this study was t...
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Melanosomes are specialized melanin-synthesizing organelles critical for photoprotection in the skin. Melanosome transfer to keratinocytes, which involves whole organelle donation to another cell, is a unique biological process and is poorly understood. Time-lapse digital movies and electron microscopy show that filopodia from melanocyte dendrites serve as conduits for melanosome transfer to ke...
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Lysosome-associated membrane proteins 1 and 2 (LAMP-1 and LAMP-2) are delivered to phagosomes during the maturation process. We used cells from LAMP-deficient mice to analyze the role of these proteins in phagosome maturation. Macrophages from LAMP-1- or LAMP-2-deficient mice displayed normal fusion of lysosomes with phagosomes. Because ablation of both the lamp-1 and lamp-2 genes yields an emb...
متن کاملLysosomes
I have followed the lysosome field since it was proposed as a concept by deDuve and his co-workers in 1955 and find this collection of papers by workers in that field an interesting addition that has many sparkling con-addition, of course, to deDuve, to name a few) but it also has several several shortcomings. For the uninitiated (and there are surprisingly many for whom "lysosome" is a new wor...
متن کاملLysosomes
Figure 1. Lysosome fusion. Lysosomes fuse with late endosomes to form endolysosomes, which are major sites of acid hydrolase activity and the digestion of endocytosed cargo. Equivalent fusions of lysosomes with phagosomes or autophagosomes can also occur (not shown in detail). Lysosomes can be reformed from endolysosomes and autolysosomes via poorly understood fi ssion and maturation processes....
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1972
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12625960